ABCA8 (ATP binding cassette subfamily A member 8)

Gene

• Entrez ID: 10351
• Gene name: ATP binding cassette subfamily A member 8
• Gene symbol: ABCA8
• Synonyms: -
• Chromosome: 17
• Chromosome location: 17q24.2
• Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct s

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT004151	hsa-miR-192-5p	Microarray	16822819
MIRT017399	hsa-miR-335-5p	Microarray	18185580
MIRT757982	hsa-miR-3170	CLIP-seq
MIRT757983	hsa-miR-338-5p	CLIP-seq
MIRT757984	hsa-miR-4260	CLIP-seq
MIRT757985	hsa-miR-548k	CLIP-seq
MIRT757986	hsa-miR-548n	CLIP-seq
MIRT757987	hsa-miR-873	CLIP-seq
MIRT1923575	hsa-miR-4504	CLIP-seq
MIRT1923576	hsa-miR-4789-5p	CLIP-seq
MIRT1923576	hsa-miR-4789-5p	CLIP-seq
MIRT1923576	hsa-miR-4789-5p	CLIP-seq
MIRT2466980	hsa-miR-1224-3p	CLIP-seq
MIRT2466981	hsa-miR-1260	CLIP-seq
MIRT2466982	hsa-miR-1260b	CLIP-seq
MIRT2466983	hsa-miR-1280	CLIP-seq
MIRT2466984	hsa-miR-183	CLIP-seq
MIRT2466985	hsa-miR-1912	CLIP-seq
MIRT2466986	hsa-miR-3065-3p	CLIP-seq
MIRT2466987	hsa-miR-3121-3p	CLIP-seq
MIRT2466988	hsa-miR-3130-5p	CLIP-seq
MIRT2466989	hsa-miR-3163	CLIP-seq
MIRT2466990	hsa-miR-3686	CLIP-seq
MIRT2466991	hsa-miR-369-3p	CLIP-seq
MIRT2466992	hsa-miR-374a	CLIP-seq
MIRT2466993	hsa-miR-374b	CLIP-seq
MIRT2466994	hsa-miR-4263	CLIP-seq
MIRT2466995	hsa-miR-4482	CLIP-seq
MIRT2466996	hsa-miR-4496	CLIP-seq
MIRT1923575	hsa-miR-4504	CLIP-seq
MIRT2466997	hsa-miR-4652-3p	CLIP-seq
MIRT2466998	hsa-miR-4773	CLIP-seq
MIRT2466999	hsa-miR-4799-5p	CLIP-seq
MIRT2467000	hsa-miR-532-3p	CLIP-seq
MIRT2467001	hsa-miR-548c-3p	CLIP-seq
MIRT2467002	hsa-miR-548l	CLIP-seq
MIRT2467003	hsa-miR-576-5p	CLIP-seq
MIRT2467004	hsa-miR-589	CLIP-seq
MIRT2466980	hsa-miR-1224-3p	CLIP-seq
MIRT2466981	hsa-miR-1260	CLIP-seq
MIRT2466982	hsa-miR-1260b	CLIP-seq
MIRT2466983	hsa-miR-1280	CLIP-seq
MIRT2466984	hsa-miR-183	CLIP-seq
MIRT2466985	hsa-miR-1912	CLIP-seq
MIRT2466986	hsa-miR-3065-3p	CLIP-seq
MIRT2466987	hsa-miR-3121-3p	CLIP-seq
MIRT2466988	hsa-miR-3130-5p	CLIP-seq
MIRT2466990	hsa-miR-3686	CLIP-seq
MIRT2466991	hsa-miR-369-3p	CLIP-seq
MIRT2466992	hsa-miR-374a	CLIP-seq
MIRT2466993	hsa-miR-374b	CLIP-seq
MIRT2466994	hsa-miR-4263	CLIP-seq
MIRT2466995	hsa-miR-4482	CLIP-seq
MIRT1923575	hsa-miR-4504	CLIP-seq
MIRT2466997	hsa-miR-4652-3p	CLIP-seq
MIRT2466998	hsa-miR-4773	CLIP-seq
MIRT2466999	hsa-miR-4799-5p	CLIP-seq
MIRT2467000	hsa-miR-532-3p	CLIP-seq
MIRT2467001	hsa-miR-548c-3p	CLIP-seq
MIRT2467003	hsa-miR-576-5p	CLIP-seq
MIRT2467004	hsa-miR-589	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005319	Function	Lipid transporter activity	IBA	21873635
GO:0005524	Function	ATP binding	IEA
GO:0005783	Component	Endoplasmic reticulum	IDA	28882873
GO:0005886	Component	Plasma membrane	IDA	28882873
GO:0005886	Component	Plasma membrane	TAS
GO:0006686	Process	Sphingomyelin biosynthetic process	IMP	23560799
GO:0006869	Process	Lipid transport	IBA	21873635
GO:0008559	Function	ABC-type xenobiotic transporter activity	IMP	12379217
GO:0010874	Process	Regulation of cholesterol efflux	IMP	28882873
GO:0010875	Process	Positive regulation of cholesterol efflux	IMP	23560799
GO:0016021	Component	Integral component of membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	ISS
GO:0030301	Process	Cholesterol transport	ISS
GO:0033344	Process	Cholesterol efflux	ISS
GO:0042626	Function	ATPase-coupled transmembrane transporter activity	IBA	21873635
GO:0042626	Function	ATPase-coupled transmembrane transporter activity	IDA	12379217
GO:0042908	Process	Xenobiotic transport	IMP	12379217
GO:0043231	Component	Intracellular membrane-bounded organelle	IBA	21873635
GO:0055085	Process	Transmembrane transport	TAS
GO:0140359	Function	ABC-type transporter activity	ISS

Other IDs

• MIM: 612505
• HGNC: 38
• e!Ensembl: ENSG00000141338

Protein

• UniProt ID: O94911
• Protein name: ABC-type organic anion transporter ABCA8 (EC 7.6.2.-) (ATP-binding cassette sub-family A member 8)
• Protein function: [Isoform 1]: Catalyzes ATP-dependent import of organic anions such as taurocholate and estrone sulfate (PubMed:12379217). In vitro, also imports ochratoxin A (PubMed:12379217). Also mediates cholesterol efflux independent of apolipoprotein, and
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12698	ABC2_membrane_3	28 → 418		Family
  PF00005	ABC_tran	499 → 654	ABC transporter	Domain
  PF12698	ABC2_membrane_3	869 → 1177		Family
  PF00005	ABC_tran	1266 → 1406	ABC transporter	Domain

• Sequence:

  MRKRKISVCQQTWALLCKNFLKKWRMKRESLMEWLNSLLLLLCLYIYPHSHQVNDFSSLL
  TMDLGRVDTFNESRFSVVYTPVTNTTQQIMNKVASTPFLAGKEVLGLPDEESIKEFTANY
  PEEIVRVTFTNTYSYHLKFLLGHGMPAKKEHKDHTAHCYETNEDVYCEVSVFWKEGFVAL
  QAAINAAIIEITTNHSVMEELMSVTGKNMKMHSFIGQSGVITDLYLFSCIISFSSFIYYA
  SVNVTRERKRMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLALVIRSTQFIILSGFM
  VVFSLFLLYGLSLVALAFLMSILVKKSFLTGLVVFLLTVFWGCLGFTSLYRHLPASLEWI
  LSLLSPFAFMLGMAQLLHLDYDLNSNAFPHPSDGSNLIVATNFMLAFDTCLYLALAIYFE
  KILPNEYGHRRPPLFFLKSSFWSQTQKTDHVALEDEMDADPSFHDSFEQAPPEFQGKEAI
  RIRNVTKEYKGKPDKIEALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSV
  TIYNNKLSEMADLENLSKLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEVDKEIQRV
  LLELEMKNIQDVLAQNLSGGQKRKLTFGIAILGDPQIFLLDEPTAGLDPFSRHQVWNLLK
  ERKTDRVILFSTQFMDEADILADRKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQLNEIC
  VEENITSLVKQHIPDAKLSAKSEGKLIYTLPLERTNKFPELYKDLDSYPDLGIENYGVSM
  TTLNEVFLKLEGKSTINESDIAILGEVQAEKADDTERLVEMEQVLSSLNKMRKTIGGVAL
  WRQQICAIARVRLLKLKHERKALLALLLILMAGFCPLLVEYTMVKIYQNSYTWELSPHLY
  FLAPGQQPHDPLTQLLIINKTGASIDDFIQSVEHQNIALEVDAFGTRNGTDDPSYNGAIT
  VCCNEKNYSFSLACNAKRLNCFPVLMDIVSNGLLGMVKPSVHIRTERSTFLENGQDNPIG
  FLAYIMFWLVLTSSCPPYIAMSSIDDYKNRARSQLRISGLSPSAYWFGQALVDVSLYFLV
  FVFIYLMSYISNFEDMLLTIIHIIQIPCAVGYSFSLIFMTYVISFIFRKGRKNSGIWSFC
  FYVVTVFSVAGFAFSIFESDIPFIFTFLIPPATMIGCLFLSSHLLFSSLFSEERMDVQPF
  LVFLIPFLHFIIFLFTLRCLEWKFGKKSMRKDPFFRISPRSSDVCQNPEEPEGEDEDVQM
  ERVRTANALNSTNFDEKPVIIASCLRKEYAGKRKGCFSKRKNKIATRNVSFCVRKGEVLG
  LLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGGDALEFLGYCPQENALWPNLTVRQHL
  EVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKTLSEGIKRKLCFVLSILGNPSVVL
  LDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIG
  SIQHLKSKFGKDYLLEMKVKNLAQVEPLHAEILRLFPQAARQERYSSLMVYKLPVEDVQP
  LAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFLELSKEQELGDFEEDFDPSVKWKLLPQEE
  P

• Sequence length: 1621