ABCA6 (ATP binding cassette subfamily A member 6)

Gene

• Entrez ID: 23460
• Gene name: ATP binding cassette subfamily A member 6
• Gene symbol: ABCA6
• Synonyms: EST155051
• Chromosome: 17
• Chromosome location: 17q24.2-q24.3
• Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24 and may play a role in macrophage lipid homeostasis. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029708	hsa-miR-26b-5p	Microarray	19088304
MIRT518539	hsa-miR-5096	PAR-CLIP	23446348
MIRT518540	hsa-miR-3157-5p	PAR-CLIP	23446348
MIRT518541	hsa-miR-3187-3p	PAR-CLIP	23446348
MIRT518542	hsa-miR-4435	PAR-CLIP	23446348
MIRT518543	hsa-miR-588	PAR-CLIP	23446348
MIRT518544	hsa-miR-4701-5p	PAR-CLIP	23446348
MIRT518545	hsa-miR-548s	PAR-CLIP	23446348
MIRT518546	hsa-miR-197-3p	PAR-CLIP	23446348
MIRT518547	hsa-miR-4653-3p	PAR-CLIP	23446348
MIRT518548	hsa-miR-8082	PAR-CLIP	23446348
MIRT518549	hsa-miR-4534	PAR-CLIP	23446348
MIRT518550	hsa-miR-6514-5p	PAR-CLIP	23446348
MIRT518551	hsa-miR-1279	PAR-CLIP	23446348
MIRT648860	hsa-miR-585-5p	HITS-CLIP	23824327
MIRT648861	hsa-miR-96-5p	HITS-CLIP	23824327
MIRT648862	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT648863	hsa-miR-4430	HITS-CLIP	23824327
MIRT648864	hsa-miR-3652	HITS-CLIP	23824327
MIRT648865	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT648866	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT648867	hsa-miR-3135b	HITS-CLIP	23824327
MIRT648868	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT648869	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT648870	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT648871	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT648872	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT648873	hsa-miR-3664-5p	HITS-CLIP	23824327

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005319	Function	Lipid transporter activity	IBA	21873635
GO:0005524	Function	ATP binding	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005886	Component	Plasma membrane	IDA	23137377
GO:0005886	Component	Plasma membrane	TAS
GO:0006869	Process	Lipid transport	IBA	21873635
GO:0016021	Component	Integral component of membrane	IEA
GO:0042626	Function	ATPase-coupled transmembrane transporter activity	IBA	21873635
GO:0043231	Component	Intracellular membrane-bounded organelle	IBA	21873635
GO:0055085	Process	Transmembrane transport	IEA

Other IDs

• MIM: 612504
• HGNC: 36
• e!Ensembl: ENSG00000154262

Protein

• UniProt ID: Q8N139
• Protein name: ATP-binding cassette sub-family A member 6 (EC 7.6.2.-)
• Protein function: Probable transporter which may play a role in macrophage lipid transport and homeostasis.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12698	ABC2_membrane_3	28 → 416		Family
  PF00005	ABC_tran	497 → 643	ABC transporter	Domain
  PF12698	ABC2_membrane_3	852 → 1214		Family
  PF00005	ABC_tran	1303 → 1441	ABC transporter	Domain

• Sequence:

  MNMKQKSVYQQTKALLCKNFLKKWRMKRESLLEWGLSILLGLCIALFSSSMRNVQFPGMA
  PQNLGRVDKFNSSSLMVVYTPISNLTQQIMNKTALAPLLKGTSVIGAPNKTHMDEILLEN
  LPYAMGIIFNETFSYKLIFFQGYNSPLWKEDFSAHCWDGYGEFSCTLTKYWNRGFVALQT
  AINTAIIEITTNHPVMEELMSVTAITMKTLPFITKNLLHNEMFILFFLLHFSPLVYFISL
  NVTKERKKSKNLMKMMGLQDSAFWLSWGLIYAGFIFIISIFVTIIITFTQIIVMTGFMVI
  FILFFLYGLSLVALVFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVFYEQLPSSLEWILN
  ICSPFAFTTGMIQIIKLDYNLNGVIFPDPSGDSYTMIATFSMLLLDGLIYLLLALYFDKI
  LPYGDERHYSPLFFLNSSSCFQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGKEAIRI
  RNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTI
  YNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQRILL
  ELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRER
  RADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHRNEICNP
  EQITSFITHHIPDAKLKTENKEKLVYTLPLERTNTFPDLFSDLDKCSDQGVTGYDISMST
  LNEVFMKLEGQSTIEQDFEQVEMIRDSESLNEMELAHSSFSEMQTAVSDMGLWRMQVFAM
  ARLRFLKLKRQTKVLLTLLLVFGIAIFPLIVENIMYAMLNEKIDWEFKNELYFLSPGQLP
  QEPRTSLLIINNTESNIEDFIKSLKHQNILLEVDDFENRNGTDGLSYNGAIIVSGKQKDY
  RFSVVCNTKRLHCFPILMNIISNGLLQMFNHTQHIRIESSPFPLSHIGLWTGLPDGSFFL
  FLVLCSISPYITMGSISDYKKNAKSQLWISGLYTSAYWCGQALVDVSFFILILLLMYLIF
  YIENMQYLLITSQIVFALVIVTPGYAASLVFFIYMISFIFRKRRKNSGLWSFYFFFASTI
  MFSITLINHFDLSILITTMVLVPSYTLLGFKTFLEVRDQEHYREFPEANFELSATDFLVC
  FIPYFQTLLFVFVLRCMELKCGKKRMRKDPVFRISPQSRDAKPNPEEPIDEDEDIQTERI
  RTATALTTSILDEKPVIIASCLHKEYAGQKKSCFSKRKKKIAARNISFCVQEGEILGLLG
  PNGAGKSSSIRMISGITKPTAGEVELKGCSSVLGHLGYCPQENVLWPMLTLREHLEVYAA
  VKGLRKADARLAIARLVSAFKLHEQLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPS
  TGIDPTGQQQMWQAIQAVVKNTERGVLLTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHL
  KNKLGKDYILELKVKETSQVTLVHTEILKLFPQAAGQERYSSLLTYKLPVADVYPLSQTF
  HKLEAVKHNFNLEEYSLSQCTLEKVFLELSKEQEVGNFDEEIDTTMRWKLLPHSDEP

• Sequence length: 1617