AADAT (aminoadipate aminotransferase)

Gene

• Entrez ID: 51166
• Gene name: Aminoadipate aminotransferase
• Gene symbol: AADAT
• Synonyms: KAT2, KATII, KYAT2
• Chromosome: 4
• Chromosome location: 4q33
• Summary: This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccarop

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT027084	hsa-miR-103a-3p	Sequencing	20371350
MIRT031647	hsa-miR-16-5p	Sequencing	20371350
MIRT756750	hsa-miR-1224-5p	CLIP-seq
MIRT756751	hsa-miR-129-5p	CLIP-seq
MIRT756752	hsa-miR-1303	CLIP-seq
MIRT756753	hsa-miR-1304	CLIP-seq
MIRT756754	hsa-miR-1972	CLIP-seq
MIRT756755	hsa-miR-3187-3p	CLIP-seq
MIRT756756	hsa-miR-340	CLIP-seq
MIRT756757	hsa-miR-3650	CLIP-seq
MIRT756758	hsa-miR-3653	CLIP-seq
MIRT756759	hsa-miR-3658	CLIP-seq
MIRT756760	hsa-miR-3915	CLIP-seq
MIRT756761	hsa-miR-3928	CLIP-seq
MIRT756762	hsa-miR-4307	CLIP-seq
MIRT756763	hsa-miR-4435	CLIP-seq
MIRT756764	hsa-miR-4502	CLIP-seq
MIRT756765	hsa-miR-450b-5p	CLIP-seq
MIRT756766	hsa-miR-4529-5p	CLIP-seq
MIRT756767	hsa-miR-4689	CLIP-seq
MIRT756768	hsa-miR-4701-5p	CLIP-seq
MIRT756769	hsa-miR-507	CLIP-seq
MIRT756770	hsa-miR-548s	CLIP-seq
MIRT756771	hsa-miR-557	CLIP-seq
MIRT756772	hsa-miR-582-5p	CLIP-seq
MIRT756773	hsa-miR-588	CLIP-seq
MIRT756774	hsa-miR-590-3p	CLIP-seq
MIRT756775	hsa-miR-759	CLIP-seq
MIRT756776	hsa-miR-877	CLIP-seq
MIRT756777	hsa-miR-103a	CLIP-seq
MIRT756778	hsa-miR-107	CLIP-seq
MIRT756779	hsa-miR-1184	CLIP-seq
MIRT756780	hsa-miR-1206	CLIP-seq
MIRT756781	hsa-miR-1245	CLIP-seq
MIRT756782	hsa-miR-1264	CLIP-seq
MIRT756783	hsa-miR-1297	CLIP-seq
MIRT756784	hsa-miR-1343	CLIP-seq
MIRT756785	hsa-miR-1470	CLIP-seq
MIRT756786	hsa-miR-15a	CLIP-seq
MIRT756787	hsa-miR-15b	CLIP-seq
MIRT756788	hsa-miR-16	CLIP-seq
MIRT756789	hsa-miR-195	CLIP-seq
MIRT756790	hsa-miR-199a-5p	CLIP-seq
MIRT756791	hsa-miR-199b-5p	CLIP-seq
MIRT756792	hsa-miR-21	CLIP-seq
MIRT756793	hsa-miR-216a	CLIP-seq
MIRT756794	hsa-miR-217	CLIP-seq
MIRT756795	hsa-miR-26a	CLIP-seq
MIRT756796	hsa-miR-26b	CLIP-seq
MIRT756797	hsa-miR-3148	CLIP-seq
MIRT756798	hsa-miR-3682-5p	CLIP-seq
MIRT756799	hsa-miR-371-5p	CLIP-seq
MIRT756800	hsa-miR-371b-5p	CLIP-seq
MIRT756801	hsa-miR-424	CLIP-seq
MIRT756802	hsa-miR-4255	CLIP-seq
MIRT756803	hsa-miR-4418	CLIP-seq
MIRT756804	hsa-miR-4452	CLIP-seq
MIRT756805	hsa-miR-4465	CLIP-seq
MIRT756806	hsa-miR-4468	CLIP-seq
MIRT756807	hsa-miR-4469	CLIP-seq
MIRT756808	hsa-miR-4659a-3p	CLIP-seq
MIRT756809	hsa-miR-4659b-3p	CLIP-seq
MIRT756810	hsa-miR-4667-3p	CLIP-seq
MIRT756811	hsa-miR-4668-3p	CLIP-seq
MIRT756812	hsa-miR-497	CLIP-seq
MIRT756813	hsa-miR-509-3-5p	CLIP-seq
MIRT756814	hsa-miR-509-5p	CLIP-seq
MIRT756815	hsa-miR-548c-3p	CLIP-seq
MIRT756816	hsa-miR-579	CLIP-seq
MIRT756817	hsa-miR-590-5p	CLIP-seq
MIRT756779	hsa-miR-1184	CLIP-seq
MIRT756792	hsa-miR-21	CLIP-seq
MIRT756794	hsa-miR-217	CLIP-seq
MIRT756757	hsa-miR-3650	CLIP-seq
MIRT756803	hsa-miR-4418	CLIP-seq
MIRT756813	hsa-miR-509-3-5p	CLIP-seq
MIRT756814	hsa-miR-509-5p	CLIP-seq
MIRT756817	hsa-miR-590-5p	CLIP-seq
MIRT756792	hsa-miR-21	CLIP-seq
MIRT756817	hsa-miR-590-5p	CLIP-seq
MIRT2442881	hsa-miR-1197	CLIP-seq
MIRT2442882	hsa-miR-3545-3p	CLIP-seq
MIRT2442883	hsa-miR-606	CLIP-seq
MIRT2442881	hsa-miR-1197	CLIP-seq
MIRT2442882	hsa-miR-3545-3p	CLIP-seq
MIRT2442883	hsa-miR-606	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0006103	Process	2-oxoglutarate metabolic process	IDA	18620547
GO:0006536	Process	Glutamate metabolic process	IDA	18620547
GO:0006554	Process	Lysine catabolic process	TAS
GO:0006569	Process	Tryptophan catabolic process	TAS
GO:0008483	Function	Transaminase activity	IBA	21873635
GO:0009058	Process	Biosynthetic process	IEA
GO:0016212	Function	Kynurenine-oxoglutarate transaminase activity	IBA	21873635
GO:0016212	Function	Kynurenine-oxoglutarate transaminase activity	IDA	18620547
GO:0030170	Function	Pyridoxal phosphate binding	IEA
GO:0033512	Process	L-lysine catabolic process to acetyl-CoA via saccharopine	IEA
GO:0042803	Function	Protein homodimerization activity	IPI	18620547
GO:0047536	Function	2-aminoadipate transaminase activity	IDA	18620547
GO:0070189	Process	Kynurenine metabolic process	IDA	18620547
GO:0097052	Process	L-kynurenine metabolic process	IEA
GO:1901605	Process	Alpha-amino acid metabolic process	IBA	21873635

Other IDs

• MIM: 611754
• HGNC: 17929
• e!Ensembl: ENSG00000109576

Protein

• UniProt ID: Q8N5Z0
• Protein name: Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (KAT/AadAT) (2-aminoadipate aminotransferase) (2-aminoadipate transaminase) (EC 2.6.1.39) (Alpha-aminoadipate aminotransferase) (AadAT) (Glycine transaminase AADAT) (EC 2.6.1.4) (Kynurenine ami
• Protein function: Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino
• PDB: 2QLR, 2R2N, 2VGZ, 2XH1, 3DC1, 3UE8, 4GDY, 4GE4, 4GE7, 4GE9, 4GEB, 5EFS, 5EUN, 5TF5, 6D0A, 6T8P, 6T8Q
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00155	Aminotran_1_2	43 → 417	Aminotransferase class I and II	Domain

• Sequence:

  MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT
  IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG
  LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP
  EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK
  FRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ
  LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV
  KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL
  IKESL

• Sequence length: 425